HPV (Human Papillomavirus)

HPV, or human papillomavirus, is a group of over 100 infections that frequently are symptom free. Approximately 30% of this group are sexually transmitted diseases (STDs) that result in contact from an infected person. One cannot be sexually active and prevent receiving HPV from an infected person, since the virus may be present on the genitals and on the skin surrounding the genitals. Any type of contact with another person's genitals or surrounding areas can transmit HPV, and most STDs can be spread without sexual intercourse.


HPV has recently received a great deal of attention because it is now known that some forms of HPV cause all forms of cervical cancer. HPV is often not noted by those infected. In some instances forms of HPV will result in genital warts that may be present on the genitals or around the anus, but frequently HPV presents no symptoms, or such insignificant symptoms that they are ignored by those infected.


HPV has no current cure. Oral medications may temporarily cause the warts to resolve. Yet like Herpes, the warts may also recur and need to be retreated at a later date. The real goal in treatment is to make the patient aware of the potential risks associated with HPV, since most diagnoses occur in the presence of an abnormal PAP smear test.


The PAP is part of what should be a yearly gynecological exam for women. It takes a tiny amount of tissue from the cervix, which is then examined by a lab to determine if any abnormal cells exist. Sometimes abnormal cells occur once only and never recur. In other cases, future pap smears will show continuing spread of abnormal cells indicating cervical cancer.


When genital warts are not present, the PAP is the only way to test for HPV. No test exists for men, which is unfortunate, since HPV may also cause penile cancer. In the absence of available testing, caution is urged by the Centers for Disease Control (CDC) of the US.


Since HPV is now indicated in a serious type of cancer, scientists are actively working to better methods for HPV diagnosis. There is also research into a possible vaccine at a future date. For now, the medical community is exerting its efforts toward education of the public about HPV, so that women will be certain not to skip their recommended yearly gynecological exams. The CDC also recommends that all who have genital warts or who have had contact with someone with HPV should discuss this with their physicians.


HPV Causes

HPV infection is caused by a virus. More than 100 types of HPV have been found. Some types cause genital warts and some can lead to cervical cancer. Types 6 and 11 cause most genital warts. Other types such as 16 and 18 are high-risk and can cause abnormal cell changes on the cervix.


How the disease is spread (transmission):



HPV Symptoms

Infection with the human papillomavirus (HPV) usually does not cause any symptoms and does not always produce visible genital warts. Some types of HPV cause cell changes to the cervix that can cause an abnormal Pap test.


When symptoms do develop, they usually occur 2 to 3 months after infection. But symptoms have been known to occur from 3 weeks to many years after infection.


Symptoms that may occur with genital warts include:



Genital warts

Genital warts can be different sizes and shapes.







In most cases, your body's immune system defeats an HPV infection before it has a chance to create any warts. When warts do appear, they may vary in appearance depending on which variety of HPV is involved:






Symptoms of genital warts may be similar to those of other conditions.


Cervical cancer

Most cases of cervical cancer are caused by two specific varieties of genital HPV. These two HPV strains usually don't cause warts, so women often don't realize they've been infected. Early stages of cervical cancer typically cause no signs or symptoms. That's why it's important for women to have regular Pap tests, which can detect precancerous changes in the cervix that may lead to cancer.


Oral and upper respiratory lesions

Some HPV infections may cause lesions to form on your tongue, tonsils, soft palate, or within your larynx and nose.


Other Conditions With Symptoms Similar to HPV Infection

Other conditions that may cause symptoms similar to genital warts caused by infection with the human papillomavirus (HPV) include:



When to see a doctor

Call your doctor if you have any of the following symptoms:



Call your doctor if you suspect you have been exposed to a sexually transmitted disease (STD). Avoid marital relations until you have been examined by a doctor.


HPV Treatment

Home Treatment

Home treatments may not cure HPV and genital warts. But a doctor may prescribe medicine that you can use at home, such as podofilox lotion or gel or imiquimod cream.


Caution: Do not use nonprescription wart removal products to treat genital warts. These products are not intended for the genital area and may cause serious burning.


You can use at-home care to feel more comfortable.



It is important to remember that most infections are minor, without serious complications. Some cases of HPV and genital warts disappear without treatment, although human papillomavirus (HPV) may still be present in your body's cells.


Medications

Medicine may be used to destroy bothersome genital warts, relieve your symptoms, and reduce the amount of area affected by warts, particularly when the warts are visible, bothersome, and growing in a small area.


Topical medicine often is the first treatment. For safety, a doctor will apply the topical medicines that could damage the skin around the warts. You can apply other medicines at home. If warts return after one course of treatment with topical medicine, they are treated again only if there are clear reasons for retreatment.


Medicines are not used to treat abnormal cell changes found on a Pap test.


Medication Choices

Treatment applied at home


The following medicines can be applied to the affected area (topical treatment) at home:



Do not use these medicines during pregnancy.


Imiquimod and podofilox appear to be the most effective medicine options that can be applied at home. Read the instructions carefully before using these medicines.


Treatment applied by a doctor


Treatment by a doctor can:



Medicines applied by a doctor include:



Treatment during pregnancy

Treatment for pregnant women includes trichloroacetic acid (TCA) and bichloroacetic acid (BCA), which have been found to be both effective and safe. Podophyllin resin, interferon, and fluorouracil should not be used during pregnancy because they can harm the fetus.


What to Think About

Avoid sexual contact until the condition is completely healed.


Some medicine may be more expensive than others.


Warts on the vulva or penis that do not go away on their own or after treatment often are biopsied to rule out precancerous or cancerous conditions.


Recurrence

Removing genital warts does not cure an HPV infection. Although warts may go away with topical treatment, they may return because the HPV virus may still be in the body's cells.


Even if genital warts have been removed or destroyed you may still be able to infect your partner with with HPV.


Surgery

You may have surgery to remove genital warts if they are widespread and medicine or freezing (cryotherapy) fails to remove them.


If you have a high-risk type of HPV that causes an abnormal Pap test, your doctor may recommend certain types of surgery. For more information about surgical methods to treat abnormal cell changes, see the topic Abnormal Pap Test.


Surgery Choices

Surgical methods that may be used include:



Surgical treatment for pregnant women

Surgical choices for pregnant women with genital warts include electrocautery, surgical excision, loop electrosurgical excision (LEEP), and laser surgery.


What to Think About

The success of surgery is related to the number of warts present. The success rate is higher and additional treatments are less likely to be required when surgery is performed on fewer and smaller warts. But surgery is less likely to be needed for a few small areas of warts.

Surgery may be more expensive than some other treatment choices.


HPV Prevention

You can reduce your risk of becoming infected with the human papillomavirus (HPV) or another sexually transmitted disease (STD). You also can reduce the risk of spreading HPV to your partner.


Practice safe sex

Preventing a sexually transmitted disease (STD) is easier than treating an infection after it occurs.






HPV Vaccines

If you are age 26 or younger, you can get the HPV shot. The vaccines Cervarix and Gardasil protect against two types of HPV that cause cervical cancer. Gardasil also protects against two types of HPV that cause genital warts. Three shots are given over 6 months. The series of shots is recommended for girls age 11 or 12 and can be given to females ages 9 to 26. Females can get either vaccine. And males ages 9 to 26 can get three Gardasil shots to reduce the chance of getting genital warts.